The Ene Lab is part of the Mycology Department at the Pasteur Institute (Paris, France).

Our work is focused on understanding how fungal cells respond and adapt to drugs. In particular, we study how individual differences between cells can allow Candida populations to escape antifungal inhibition. Antifungal tolerance and heteroresistance have been recently described in fungi and we seek to understand the mechanisms enabling these phenomena. To address these questions, we combine tools in molecular biology, genomics, transcriptomics, and animal models of infections.

Interested in working with us? We are looking for motivated students and postdocs to join our team. To apply, please email Jules .

We currently have a postdoc position on an ANR funded project. Read more about it here.

Iuliana (Jules) Ene

I am currently a CIFAR Global Scholar in the Fungal Kingdom: Threats & Opportunities Program. Previously, I was a Research Assistant Professor of Molecular Microbiology and Immunology at Brown University. Prior to starting my group at Brown, I did a postdoc with Prof Richard Bennett in the same department. I received my PhD from the University of Aberdeen in 2012, where I worked with Prof Al Brown as part of the Aberdeen Fungal Group (now the MRC Center for Medical Mycology).


Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract
McDonough L, Mishra AA, Tosini N, Kakade P, Penumutchu S, Liang SH, Maufrais C, Zhai B, Taur Y, Belenky P, Bennett RJ*, Hohl TM*, Koh AY*, Ene IV*
mBio 2021

The Interplay Between Neutral and Adaptive Processes Shapes Genetic Variation During Candida Species Evolution
Ene IV, Hickman MA, Gerstein AC
Current Clinical Microbiology Reports 2021

Adaptation to the dietary sugar D-tagatose via genome instability in polyploid Candida albicans cells
Thomson GJ, Kakade P, Hirakawa MP, Ene IV*, Bennett RJ*
G3 Genes| Genomes| Genetics 2021

Mechanisms of genome evolution in Candida albicans
Ene IV, Bennett RJ, Anderson MZ
Current Opinion in Microbiology 2019

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism
Liang SH, Anderson MZ, Hirakawa MP, Wang JM, Frazer C, Alaalm LM, Thomson GJ, Ene IV, Bennett RJ
Cell Host and Microbe 2019

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
Ene IV, Farrer RA, Hirakawa MP, Agwamba K, Cuomo CA, Bennett RJ
PNAS 2018

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
Rosenberg A*, Ene IV*, Bibi M, Zakin S, Segal ES, Ziv N, Dahan AM, Colombo AL, Bennett RJ, Berman J
Nature Communications 2018
*indicates equal contributions
associated article on the Nature Microbiology Community blog

Systematic Genetic Screen for Transcriptional Regulators of the Candida albicans White-Opaque Switch
Lohse MB, Ene IV, Craik VB, Hernday AD, Mancera E, Morschhäuser J, Bennett RJ, Johnson AD
Genetics 2016

Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance
Ene IV, Walker LA, Schiavone M, Lee KK, Martin-Yken H, Dague E, Gow NA, Munro CA, Brown AJ
mBio 2015

Metabolism in fungal pathogenesis
Ene IV, Brunke S, Brown AJ, Hube B
Cold Spring Harbor Perspectives in Medicine 2014

The cryptic sexual strategies of human fungal pathogens
Ene IV, Bennett RJ
Nature Reviews Microbiology 2014

Integration of metabolism with virulence in Candida albicans
Ene IV, Brown AJ
Fungal Genomics, The Mycota XIII 2014 (book chapter)

Stress adaptation in a pathogenic fungus
Brown AJ, Budge S, Kaloriti D, Tillmann A, Jacobsen MD, Yin Z, Ene IV, Bohovych I, Sandai D, Kastora S, Potrykus J, Ballou ER, Childers DS, Shahana S, Leach MD
Journal of Experimental Biology 2014

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans
Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, Bohovych I, Ene IV, Kastora S, Budge S, Munro CA, Odds FC, Gow NA, Brown AJ
mBio 2012

Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans
Ene IV, Heilmann CJ, Sorgo AG, Walker LA, de Koster CG, Munro CA, Klis FM, Brown AJ
Proteomics 2012 (journal cover)

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen
Ene IV, Adya AK, Wehmeier S, Brand AC, MacCallum DM, Gow NA, Brown AJ
Cellular Microbiology 2012 (editor's choice)